There are many, many spoilers in this review.
Amy is missing, yes. Her blood is at her and her husband’s home along with a shattered glass table and an open front door. Her porcelain skin, glowing smile and flowing golden hair is plastered desperately on “Missing” billboards and posters by her loved ones. The media quickly catches Missing White Woman Syndrome and flocks to the scene to revel in and exploit the spectacle. They want more blood, her husband’s blood, and the police are gradually running out of reasons not to give it to them.
None of them seem willing (or able) to fathom that Amy (Rosamund Pike) would flee on her own free will, let alone her other, more sociopathic impulses. It takes her clumsy, baffled husband Nick (Ben Affleck) a while to realize he’s ensnared in an intricate, sadistic web by his wife. However, she’s also caught in a different but equally sinister web with everyone else in the movie, one woven by David Fincher and Gillian Flynn.